UMD     This Site

The proposed platform.

The proposed platform.


Complementary metal-oxide-semiconductor (CMOS)-based microelectronic sensors have great potential in the development of biosensors for medical and life science applications. Lab-on-CMOS microsystems incorporate one or more CMOS chips that can perform laboratory functions directly on the surface of the chips, allowing for intimate contact between sensing inputs and the cells under analysis. However, validating these lab-on-CMOS systems is a challenging task because of the difficulties in obtaining simultaneous ground-truth imaging and sensor data.

ISR-affiliated Professor Elisabeth Smela (ME), Professor Pamela Abshire (ECE/ISR), and two of Abshire’s graduate students, Bathiya Senevirathna and Sheung Luhave, have developed the first real-time imaging platform that generates high-quality images of lab-on-CMOS systems in cell culture environments. The platform was used to validate a CMOS capacitance sensor that monitors cell viability, proliferation, and death.

Several in vitro experiments were performed with human ovarian cancer cell lines where time-lapse images and capacitance recordings were performed simultaneously over three days. The images not only corroborated the temporal changes of capacitance recordings as the cells proliferated, but also unambiguously confirmed the sensor’s ability to detect single-cell binding events, track cell morphology changes, identify cell division events, and monitor cell motility.

An Imaging Platform for Real-Time In Vitro Microscopic Imaging for Lab-on-CMOS Systems,” a paper based on their work, was presented at the 2019 IEEE Biomedical Circuits and Systems Conference (BioCAS).

Related Articles:
Alum Marc Dandin Appointed to Carnegie Mellon Faculty
Decade of TMV research leads to never-before-seen microsystems for energy storage, biosensors and self-sustaining systems
Chapin, Bowen win in Bioscience Day poster session
Goldsman and colleagues awarded US Patent for SiC-integrated circuit active photodetector
NSF Awards $1M Grant to UMD Researchers
Ghodssi Receives Senior Faculty Outstanding Research Award
Students advance in Qualcomm Innovation Fellowship competition
‘Smart Marbles’ hold promise for better outcomes from bioreactors
Schizophrenia drug monitoring device research featured on IEEE Sensors Letters cover
Nima Ghalichechian begins Ohio State tenure-track position 

December 11, 2019

«Previous Story  



Current Headlines

Ephremides and colleagues consider Age of Information scheduling problem for interconnected sensors

Clark School researchers test decentralized task allocation algorithms for UAV teams

Nuno Martins, alum Shinkyu Park and Jeff Shamma lead tutorial session at IEEE CDC 2019

UMD Online Engineering Graduate Program Ranks 18th Nationally

ISR alum honors former advisor Benjamin Kedem with quantile frequency analysis paper

Hybrid compositional planning for UAV rescue missions

Who's walking deceptively? Manocha's team thinks they know.

Chakraborty, Seneviratne, and Zou Named Outstanding Graduate Assistants

Data fusion modeling can estimate residential radon levels

Ryzhov, Chen develop theoretical framework for approximate Bayesian learning

Back to top  
Home Clark School Home UMD Home